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The restraints that adopted from the default setting in the CHARM-GUI webserver v3.2.2 57 were reduced gradually over 50 ns, with a simulation step of 1 fs (see Supplementary Table 5 for more details)

The dosage is escalated every four weeks, according to the patients tolerance

Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Wettergren A, Svendsen LB et al

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These problems are not common in most people of reproductive age, but they may be more likely in those with a history of pelvic floor issues or pelvic surgeries